Zsuzsanna Helyes Selected Research

Neuralgia (Stump Neuralgia)

1/2023	The heptapeptide somatostatin analogue TT-232 exerts analgesic and anti-inflammatory actions via SST4 receptor activation: In silico, in vitro and in vivo evidence in mice.
6/2021	Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain.
12/2020	Radiosynthesis and Preclinical Investigation of 11 C-Labelled 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanal Oxime ([11 C]SZV 1287).
1/2020	In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists.
12/2019	Novel Drug-Like Somatostatin Receptor 4 Agonists are Potential Analgesics for Neuropathic Pain.
1/2017	Involvement of substance P in the antinociceptive effect of botulinum toxin type A: Evidence from knockout mice.
9/2003	Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat.

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Zsuzsanna Helyes Research Topics

Disease

59	Inflammation (Inflammations) 01/2023 - 05/2004
48	Pain (Aches) 04/2024 - 09/2004
44	Hyperalgesia 03/2023 - 08/2002
24	Arthritis (Polyarthritis) 03/2024 - 05/2004
15	Edema (Dropsy) 03/2024 - 05/2007
15	Migraine Disorders (Migraine) 12/2023 - 01/2012
11	Neurogenic Inflammation 05/2023 - 08/2002
8	Rheumatoid Arthritis 03/2024 - 10/2014
8	Pneumonia (Pneumonitis) 06/2022 - 01/2008
7	Neuralgia (Stump Neuralgia) 01/2023 - 09/2003
6	Chronic Pain 01/2024 - 06/2006
6	Headache (Headaches) 09/2022 - 01/2012
6	Hypersensitivity (Allergy) 02/2021 - 08/2009
6	Colitis 01/2019 - 09/2010
5	Neuroinflammatory Diseases 01/2023 - 04/2020
5	Body Weight (Weight, Body) 05/2022 - 01/2016
5	Bronchial Hyperreactivity 06/2020 - 05/2007
5	Hyperplasia 02/2015 - 05/2007
4	Neoplasms (Cancer) 03/2024 - 01/2021
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 03/2019 - 09/2010
3	Experimental Arthritis 03/2024 - 07/2005
3	Squamous Cell Carcinoma of Head and Neck 07/2023 - 09/2020
3	Chronic Obstructive Pulmonary Disease (COPD) 04/2022 - 10/2017
3	Complex Regional Pain Syndromes 03/2022 - 02/2014
3	Infections 01/2022 - 01/2006
3	Reperfusion Injury 01/2021 - 04/2011
3	Dermatitis 01/2016 - 12/2005
3	Allergic Contact Dermatitis 01/2016 - 12/2005
3	Ischemia 04/2011 - 11/2010
2	Acute Pain 04/2024 - 09/2004
2	Disease Progression 03/2024 - 07/2023
2	Necrosis 01/2023 - 12/2017
2	Heart Failure 07/2022 - 03/2022

Drug/Important Bio-Agent (IBA)

28	Capsaicin (Zostrix)FDA Link 07/2023 - 05/2004
20	Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA 03/2022 - 01/2009
19	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 07/2023 - 08/2002
19	NeuropeptidesIBA 07/2022 - 08/2002
18	Analgesics (Analgesic Drugs)IBA 04/2024 - 05/2004
14	Peroxidase (Myeloperoxidase)IBA 01/2023 - 05/2007
11	AnkyrinsIBA 03/2024 - 01/2016
11	CytokinesIBA 01/2023 - 10/2010
11	resiniferatoxinIBA 02/2021 - 09/2003
9	Ion Channels (Ion Channel)IBA 04/2024 - 01/2017
9	Freund's AdjuvantIBA 03/2024 - 05/2004
9	Substance PIBA 11/2023 - 06/2007
9	TachykininsIBA 01/2023 - 10/2010
8	Peptides (Polypeptides)IBA 12/2023 - 10/2010
8	CarrageenanIBA 01/2023 - 10/2005
8	EndotoxinsIBA 06/2022 - 05/2007
7	hemokinin-1IBA 11/2023 - 01/2013
7	AutoantibodiesIBA 01/2023 - 02/2014
7	TRPV1 receptorIBA 10/2017 - 07/2005
6	Messenger RNA (mRNA)IBA 11/2023 - 12/2009
6	somatostatin receptor subtype-4IBA 01/2023 - 06/2006
6	Proteins (Proteins, Gene)FDA Link 01/2023 - 09/2015
6	SmokeIBA 04/2022 - 04/2016
6	Formaldehyde (Formol)FDA Link 01/2018 - 09/2004
5	LipidsIBA 04/2024 - 05/2015
5	Calcitonin Gene-Related PeptideIBA 12/2023 - 06/2007
5	TT2-32IBA 01/2023 - 08/2002
5	Immunoglobulin G (IgG)IBA 03/2022 - 02/2014
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 08/2009
5	Streptozocin (Streptozotocin)FDA Link 10/2021 - 09/2004
5	LipopolysaccharidesIBA 06/2020 - 05/2007
4	Opioid Analgesics (Opioids)IBA 01/2024 - 10/2016
4	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 01/2024 - 10/2010
4	Amine Oxidase (Copper-Containing)IBA 02/2021 - 01/2017
4	GTP-Binding Proteins (G-Protein)IBA 01/2020 - 11/2006
3	SphingolipidsIBA 04/2024 - 01/2020
3	CationsIBA 03/2024 - 01/2020
3	Biomarkers (Surrogate Marker)IBA 03/2024 - 01/2018
3	CalciumIBA 03/2023 - 01/2017
3	Interleukin-6 (Interleukin 6)IBA 01/2023 - 02/2015
3	Tachykinin Receptors (Tachykinin Receptor)IBA 01/2023 - 05/2013
3	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2023 - 01/2008
3	Blood Glucose (Blood Sugar)IBA 10/2021 - 03/2016
3	Antidepressive Agents (Antidepressants)IBA 10/2020 - 01/2017
3	LigandsIBA 01/2020 - 01/2016
3	incobotulinumtoxinA FDA Link 01/2019 - 01/2016
3	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 03/2015
3	Dextrans (Dextran)FDA Link 01/2019 - 01/2014
3	Acetic Acid (Vinegar)FDA LinkGeneric 10/2016 - 06/2007
3	GalaninIBA 01/2016 - 01/2015
3	Dextran SulfateIBA 01/2016 - 09/2010
3	OxazoloneIBA 01/2016 - 08/2009
2	CholesterolIBA 04/2024 - 01/2024
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 04/2024 - 01/2020
2	VaccinesIBA 03/2024 - 01/2022
2	Therapeutic UsesIBA 01/2024 - 07/2022
2	Opioid Receptors (Opioid Receptor)IBA 01/2024 - 01/2020
2	Interleukin-1 (Interleukin 1)IBA 03/2023 - 01/2020
2	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 01/2023 - 01/2018
2	src-Family KinasesIBA 01/2023 - 09/2014
2	AntibodiesIBA 03/2022 - 01/2022

Therapy/Procedure

19	Therapeutics 01/2024 - 10/2005
10	Ligation 11/2020 - 09/2003
4	Oral Administration 11/2020 - 05/2014
3	Drug Therapy (Chemotherapy) 07/2023 - 01/2017
3	Subcutaneous Injections 01/2022 - 05/2004
3	Injections 02/2021 - 01/2016